Tuesday, April 30, 2013

Jon Jones, Pat Healy and Sara McMann: UFC 159?s Three Stars

UFC 159 was a bizarre event ? possibly cursed by demons ? but there were still plenty of standout performances by fighters whose bouts ended normally. Who stood out for you? Speak up on Twitter or on Facebook.

No. 1 star -- Jon Jones: As we've said since the fight was made, Chael Sonnen was not the right competition for UFC light heavyweight Jones because he is middleweight coming off of a loss. Jones could have taken Sonnen lightly and still probably won, but he didn't do that. He used the fight as another opportunity to show his dominance, beating Sonnen at his own game by taking him down several times before finishing the fight near the end of the first round.

Would the fight have been stopped if they made it out of the first round, and the referee had noticed Jones' mangled toe? Who cares? It didn't happen, and Jones is still the champ.

No. 2 star -- Pat Healy: The UFC's already stacked lightweight division somehow got even tough with Healy's performance on Saturday night. Along with Jim Miller, he put on a show then finished the fight in the third round. He won both Fight of the Night and Submission of the Night, meaning Healy walked away with an extra $130,000.

No. 3 star -- Sara McMann: As an Olympic silver medal-winning wrestler, McMann is one of the most decorated athletes to join the UFC. This means she had big expectations to perform, and she exceeded them. McMann used wrestling and power to stop Sheila Gaff in the first round.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/jon-jones-pat-healy-sara-mcmann-ufc-159-132329967.html

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Monday, April 29, 2013

Demand drives TVA renewable energy projects

KNOXVILLE, Tenn. (AP) -- The Tennessee Valley Authority has approved more than 250 small-scale renewable energy projects for 2013, the overwhelming majority relying on solar energy.

TVA officials say the demand for renewable energy projects across the Tennessee Valley is strong ? so strong that the agency has met its application goals for 2013.

TVA has been working with local power companies since January to approve applications for renewable energy systems as part of its Green Power Providers program. Officials say all but two of the 250 projects are solar installations.

The agency has also met its application goals under the Solar Solutions Initiative pilot program, which promotes green jobs in the region.

TVA is a corporate agency of the U.S. government that provides power to 9 million people in seven southeastern states.

Source: http://news.yahoo.com/demand-drives-tva-renewable-energy-152422230.html

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Things To Consider When Looking For A Beginner's Music Lessons ...

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Source: http://entertain-art.blogspot.com/2013/04/things-to-consider-when-looking-for.html

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Friday, April 26, 2013

US-MUSIC Summary

Mamma Mia! Bookie offers odds on ABBA reunion

LONDON (Reuters) - A British bookmaker is taking bets on an ABBA comeback after singer Agnetha Faltskog hinted at a possible reunion for Sweden's most successful band. Faltskog, who has come out of retirement to release a solo album called "A", was asked by German's Die Zeit Magazine if she would be open to an ABBA reunion and she responded positively.

Psy knocked from top of Korean charts by 63-year-old singer

SEOUL (Reuters) - South Korean rapper Psy, whose latest video "Gentleman" tracked global megahit "Gangnam Style" by going viral on the Internet, has been knocked from the top of the music charts in his native country by a 63-year-old easy listening pop singer. "Gangnam Style", which holds the YouTube record for most views with more than 1.5 billion, catapulted the sunglassed Korean with the garish jackets to world stardom and made him one of the best-known faces to grace the growing K-pop music scene.

Documentary about deceased British singer Amy Winehouse in the works

(Reuters) - A documentary is in the works about the late British soul singer Amy Winehouse and it features previously unseen material, the film's distributor said on Wednesday. The film, which will include archival footage never seen by the public, will be directed by Briton Asif Kapadia, whose 2010 film "Senna," about Brazilian auto racer Ayrton Senna, won a BAFTA for best documentary.

Kurdish singer sparks identity debate on Arab talent show

ARBIL, Iraq (Reuters) - A singer from Iraq's Kurdistan region has made it through to the semi-final of an Arab talent contest, igniting heated debates over Iraqi identity and politicizing the popular TV show. A panel of judges praised 24-year-old Parwaz Hussein and she was voted through to the next round of "Arab Idol", in which aspiring popstars from Morocco to Bahrain compete for a recording contract.

Swedish police find drugs on Justin Bieber bus, no suspects

STOCKHOLM (Reuters) - Swedish police said on Thursday they found drugs on teen idol Justin Bieber's tour bus in Stockholm, but had no suspects and were unlikely to pursue the case further. A police officer on crowd duty smelled marijuana on an empty tour bus outside the hotel where Bieber was staying just before his concert in the capital on Wednesday night, police spokesman Kjell Lindgren said.

Michael Jackson wrongful death trial set to get underway Monday

LOS ANGELES (Reuters) - The civil trial over the death of Michael Jackson is set to get formally underway next week after jury selection was completed on Tuesday in the $40 billion case that pits the pop star's mother against concert promoters AEG Live. Six alternate jurors were chosen on Tuesday following the selection a day earlier of a jury of six men and six women for what is expected to be an emotional three-month trial.

Fall Out Boy outsells Kid Cudi for top spot on Billboard chart

LOS ANGELES (Reuters) - U.S. rock band Fall Out Boy topped the Billboard 200 weekly best-selling album chart for the second time in their five-album career, besting rapper Kid Cudi. "Save Rock and Roll" sold 154,000 copies in its debut week, according figures on Wednesday from Nielsen SoundScan, outpacing Kid Cudi's "Indicud," which sold 136,000 copies in its first week.

Singer Lauryn Hill gets reprieve on tax evasion sentencing

NEWARK (Reuters) - Grammy Award-winning singer Lauryn Hill was given a two-week reprieve on her sentencing for federal tax evasion on Monday as a federal judge admonished her defense counsel for failing to come up with most of the tax money promised prior to her scheduled hearing. Hill, a solo artist and a member of the Fugees rap trio, pleaded guilty in June 2012 to failure to file federal tax returns from 2005-2007, when she earned $1.8 million. She faces up to a year in prison for each charge.

Backstreet Boys get Hollywood star ahead of world tour

LOS ANGELES (Reuters) - Boy band the Backstreet Boys - now all grown men - on Monday marked their 20th anniversary and their upcoming world tour by getting a star on the Hollywood Walk of Fame. "Backstreet is Back ... and we aren't going anywhere," Nick Carter, 33, told fans as all five members of the 1990s band gathered to unveil their star - located right next to another popular boy band, Boyz II Men.

Folk musician Richie Havens dead at 72

LOS ANGELES (Reuters) - U.S. folk musician Richie Havens, who opened the historic 1969 Woodstock musical festival and energized the crowd with his version of "Motherless Child/Freedom," died of a heart attack on Monday at the age of 72, his talent agency said. Havens, who emerged from the New York folk scene in the 1960s and went on to sing for the Dalai Lama and President Bill Clinton, died at his home in Jersey City, New Jersey, Roots Agency President Tim Drake told Reuters.

Source: http://news.yahoo.com/us-music-summary-081908906.html

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Obama to meet business executives ahead of Central American trip

WASHINGTON (Reuters) - President Barack Obama will meet on Friday with a group of U.S. business executives whose companies have a major presence in Mexico and Central America, the White House said on Thursday.

Obama departs for a trip to Mexico and Costa Rica next week.

Here is the list of business leaders expected to meet with him at the White House:

John Bilbrey, chief executive, Hershey Co

Franklin Chang D?az, president, Ad Astra Rocket Company

Andres Gluski, chief executive, AES Corp

Robert A. McDonald, chief executive, Procter & Gamble Co

Manuel Medina-Mora, co-president, Citigroup and chairman, Banamex

Luis Alberto Moreno, president, Inter-American Development Bank

J. Miles Reiter, chief executive, Driscoll's

Mark Snell, president, Sempra Energy

David Starling, chief executive, Kansas City Southern

Patricia Woertz, chief executive, Archer Daniels Midland

(Reporting by Jeff Mason; Editing by Paul Simao)

Source: http://news.yahoo.com/obama-meet-business-executives-ahead-central-american-trip-005605086.html

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East London Tech City Startups To Get Access To Network Of 4G Hotspots In June

east-london-06The Tech City high tech cluster in London's East End is getting an extra helping of high speed mobile connectivity from June. Carrier EE, which owns and operates the U.K.'s first and still only LTE/4G network, has announced it is partnering with the area's quango, the Tech City Investment Organisation, to install a network of 4G hotspots in "key locations" for businesses in the area to use.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/L4BVVGzfMPw/

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After Raising $6.7M For Startups And Winning SEC Approval, AngelList Opens Up Investment Platform To More Companies

angellist-1In December, AngelList, a service that matches early stage startups with investors, debuted the ability to allow accredited investors to actually invest in startups on the platform with as little as $1,000. AngelList also partnered with SecondMarket to create an investment vehicle for these investments. Since December, the company is announcing that it has seen 1,100 investment commitments completely online, totaling over $6 million in funding for startups raising via AngelList. And today, AngelList is opening the platform up to all startups with top-tier investors.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/i5OXA8avxcE/

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Four Realistic Ways to Cut Your Commuting Costs

Last week as I pulled into the gas station, I felt a series of heart palpitations as I read the prices of gas: $4.09, $4.19, $4.29. While I realize this is lower than some people are currently paying in other parts of the country, I couldn?t help but think of the millions of people who are working, in part, simply to pay for the ?luxury? of driving to and from their workplace.

This is a guest post from Quizzle.com.

My guess is that all of us are working for our paycheck for many reasons?none of which include simply handing over a good chunk of it to the gas station. But if you?re stuck with a daunting commute that necessitates multiple fill-ups each month, what can you do to reduce your commuting costs?

Here are some of the methods I?ve employed to drastically cut commuting costs over the years:

Change Your Work Hours

If you?re not working a traditional shift job and you have some flexibility with your scheduling (or an understanding boss), consider negotiating alternate hours outside of the 9-5. Perhaps you could try coming in early and leaving early or coming in late and leaving late (ideally, it?s not coming in early and leaving late!). By switching up your hours, you could avoid a lot of traffic?especially stop and go traffic which absolutely kills your gas mileage.

Partner Up

Carpooling is a great way to save money, be social, and reduce the chance of driving-induced stress (yes, I?m talking about road rage here, people). Even if you only commit to carpooling two days/week, you can reduce your costs for gas as well as the wear and tear on your vehicle.

If you?re thinking about carpooling, reach out to some close co-workers, solicit options via company message boards and email lists, or make an appointment with your HR rep to see what you can do to set up a car/ride sharing program at your work.

Travel With the Masses

I?ll be the first one to admit that I hate public transit?especially during rush hour. The packed trains and disgruntled passengers can leave a lot to be desired, but it?s a phenomenal way to save money on your commuting expenses.

If you live in an urban area, chances are your employer may participate in a reduced fare program. I?ve taken advantage of such a deal through my part-time job as I pay a mere $32/month for an unlimited bus/subway pass thanks to my employer?s generous subsidy. When I think of the hundreds I save each year, those minor hassles with the crowded trains are a bit more palatable.

Consider Radical Alternatives

If none of these options appeal to you or aren?t feasible for your situation, consider a more radical approach. This could mean forgoing the car altogether in favor of a bicycle, petitioning to work from home more often, or it could go as far as changing jobs.

Realistic Ways to Cut Your Commuting Costs | Quizzle


For more tips and tools to help you manage your home, money and credit?including the most affordable credit monitoring on the web and complete identity theft protection?visit Quizzle.com. Quizzle is a website that provides you with important information about your credit?starting with your credit report and credit score?as well as the tools you need to improve or monitor it, so you can make smart financial decisions. They also show you how your credit impacts your personal finances and give you personalized tips and tools to help you manage it all.

Image remixed from Sergey Peterman (Shutterstock), Next Please Stop (Flickr), and Teosaurio (Flickr).

Want to see your work on Lifehacker? Email Tessa.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ahf1GkjbaEs/four-realistic-ways-to-cut-your-commuting-costs-479728266

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Thursday, April 25, 2013

Nanowires grown on graphene have surprising structure

Wednesday, April 24, 2013

When a team of University of Illinois engineers set out to grow nanowires of a compound semiconductor on top of a sheet of graphene, they did not expect to discover a new paradigm of epitaxy.

The self-assembled wires have a core of one composition and an outer layer of another, a desired trait for many advanced electronics applications. Led by professor Xiuling Li, in collaboration with professors Eric Pop and Joseph Lyding, all professors of electrical and computer engineering, the team published its findings in the journal Nano Letters.

Nanowires, tiny strings of semiconductor material, have great potential for applications in transistors, solar cells, lasers, sensors and more.

"Nanowires are really the major building blocks of future nano-devices," said postdoctoral researcher Parsian Mohseni, first author of the study. "Nanowires are components that can be used, based on what material you grow them out of, for any functional electronics application."

Li's group uses a method called van der Waals epitaxy to grow nanowires from the bottom up on a flat substrate of semiconductor materials, such as silicon. The nanowires are made of a class of materials called III-V (three-five), compound semiconductors that hold particular promise for applications involving light, such as solar cells or lasers.

The group previously reported growing III-V nanowires on silicon. While silicon is the most widely used material in devices, it has a number of shortcomings. Now, the group has grown nanowires of the material indium gallium arsenide (InGaAs) on a sheet of graphene, a 1-atom-thick sheet of carbon with exceptional physical and conductive properties.

Thanks to its thinness, graphene is flexible, while silicon is rigid and brittle. It also conducts like a metal, allowing for direct electrical contact to the nanowires. Furthermore, it is inexpensive, flaked off from a block of graphite or grown from carbon gases.

"One of the reasons we want to grow on graphene is to stay away from thick and expensive substrates," Mohseni said. "About 80 percent of the manufacturing cost of a conventional solar cell comes from the substrate itself. We've done away with that by just using graphene. Not only are there inherent cost benefits, we're also introducing functionality that a typical substrate doesn't have."

The researchers pump gases containing gallium, indium and arsenic into a chamber with a graphene sheet. The nanowires self-assemble, growing by themselves into a dense carpet of vertical wires across the surface of the graphene. Other groups have grown nanowires on graphene with compound semiconductors that only have two elements, but by using three elements, the Illinois group made a unique finding: The InGaAs wires grown on graphene spontaneously segregate into an indium arsenide (InAs) core with an InGaAs shell around the outside of the wire.

"This is unexpected," Li said. "A lot of devices require a core-shell architecture. Normally you grow the core in one growth condition and change conditions to grow the shell on the outside. This is spontaneous, done in one step. The other good thing is that since it's a spontaneous segregation, it produces a perfect interface."

So what causes this spontaneous core-shell structure? By coincidence, the distance between atoms in a crystal of InAs is nearly the same as the distance between whole numbers of carbon atoms in a sheet of graphene. So, when the gases are piped into the chamber and the material begins to crystallize, InAs settles into place on the graphene, a near-perfect fit, while the gallium compound settles on the outside of the wires. This was unexpected, because normally, with van der Waals epitaxy, the respective crystal structures of the material and the substrate are not supposed to matter.

"We didn't expect it, but once we saw it, it made sense," Mohseni said.

In addition, by tuning the ratio of gallium to indium in the semiconductor cocktail, the researchers can tune the optical and conductive properties of the nanowires.

Next, Li's group plans to make solar cells and other optoelectronic devices with their graphene-grown nanowires. Thanks to both the wires' ternary composition and graphene's flexibility and conductivity, Li hopes to integrate the wires in a broad spectrum of applications.

"We basically discovered a new phenomenon that confirms that registry does count in van der Waals epitaxy," Li said.

###

University of Illinois at Urbana-Champaign: http://www.uiuc.edu

Thanks to University of Illinois at Urbana-Champaign for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 38 time(s).

Source: http://www.labspaces.net/127884/Nanowires_grown_on_graphene_have_surprising_structure

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Space Archaeologists Call for Preserving Off-Earth Artifacts

When it comes to preserving history, a group of archaeologists and historians are hoping to boldly go where no archaeologist has gone before.

Researchers are increasingly urging humanity to protect off-Earth cultural resources. That may well mean preserving NASA's Apollo landing sites on the moon as national historic landmarks, regarding far-flung spacecraft as mobile artifacts and even working to preserve some pieces of space junk.

"The cultural landscape of space includes both sites and objects on and off Earth," said Beth O'Leary, an associate professor of anthropology at the University of New Mexico in Las Cruces. "It is necessary to evaluate the significance of the latter and treat them as important objects and places worthy of legitimate archaeological inquiry." [Historic Apollo Moon Landers Found! (Photos)]

O'Leary spearheaded a NASA-funded effort to make the 1969 Apollo 11 lunar landing site a national historic landmark. She and other experts in the emerging field of space archaeology gathered at the annual meeting of the Society for American Archaeology (SAA), held April 3-7 in Honolulu.

Legitimate archaeological inquiry

O'Leary and Lisa Westwood of California State University, Chico co-chaired the SAA session on space archaeology. The field seeks to scrutinize the routes for preservation of space objects and places.

Westwood said that in 1972 ? near the end of the Apollo program ? the General Conference of the United Nations Educational, Scientific, and Cultural Organization (UNESCO) adopted the World Heritage Convention in a pioneering effort to protect universally important monuments, buildings, archaeological sites,and natural and cultural landscapes from being depleted.

"At that time and within that context, cultural heritage was defined by its location relative to then-current political boundaries on Earth. We now can broaden that view to encompass many other historic properties on Earth, on the moon and beyond," Westwood said.

In applying a cultural landscape approach to early space exploration heritage, she asked: Is it possible to designate a World Heritage List district of sites and properties that spans not only multiple countries, but planetary bodies as well?

Historic preservation

"I am a preservationist trying to protect a human archeological site 233,000 miles away," said Joe Reynolds of Clemson University in South Carolina. He detailed his analysis of international space law and how it affects historic preservation.

From 1969 to 1972, NASA's Apollo astronauts completed six separate lunar landing missions, "creating historically significant sites that now sit frozen in the lunar desert," Reynolds said.

Protection of lunar sites is complicated by the Outer Space Treaty of 1967, which prohibits countries from exercising territorial sovereignty over the moon or other celestial bodies.

Reynolds reviewed international treaties, such as those governing the ocean floor, Antarctica and the heavens. He also examined the language of the World Heritage Convention, the Geneva Convention, the National Historic Preservation Act of 1966, The Antiquities Act of 1906 and various state preservation laws.

"The Apollo 11 Lunar Landing Site can be legally protected," Reynolds said. "What my colleagues and I are trying to accomplish is to legally protect a site of unprecedented human achievement on land that cannot be owned by anyone."

Conserve and protect base camps

According to Reynolds, legal protection of historic or culturally significant sites on land not claimed by any nation is not unprecedented. "There are areas on Earth that share the designation of Res Communis with the moon, such as international waters and the Antarctic continent, and there are a few examples of preservation in those areas," he said.

One example Reynolds cited is the New Zealand Antarctic Heritage Trust. Created in 1987, NZAHT is focused on conserving and protecting the base camps for the four major Antarctic explorations of the early 20th century.

"The Apollo 11 Lunar Landing Site is similar to the camps protected by the NZAHT because at the most basic level, the objects left on the moon are more or less just another base camp, for another historic scientific expedition, on land that cannot be owned by anyone," Reynolds said.

The objects left on the moon by Apollo 11 moonwalkers Neil Armstrong and Buzz Aldrin are U.S. government property. Ownership of those objects has never been relinquished.

"This makes the legal protection of these objects a very simple classroom exercise," Reynolds said. "However, getting Congress to agree to it ? or anything these days ? is another story. One of the reasons for a lack of action to protect this site on the moon may be because it could be construed as a claim of sovereignty on the lunar surface."

Pinnacle of American bravado

Reynolds thinks the Apollo 11 Lunar Landing Site could become a national monument with the stroke of a U.S. president's pen. The Antiquities Act of 1906, he said, gives the president the power to create national monuments via executive order.

Congress could also allow for the protection of the site by passing the Tranquility Base National Historic Landmark Act, written by Reynolds' colleagues Westwood and O'Leary.

The Apollo moon landing sites should be included as national historic landmarks, Reynolds said, because they may represent "the pinnacle of American bravado ... [the] physical manifestation of that innovation, hope and discovery. That is why the U.S. should preserve these sites," he concluded.

Robot avatars

Nearer to planet Earth, Alice Gorman of Flinders University in Australia sees cultural value in orbiting space junk.

There are thousands of defunct satellites, rocket bodies and other pieces of junk currently in Earth orbit. Gorman called this cloud "a robotic colonial frontier" that reflects the nature of our social and political interactions with space and adaptations to a new environment. [Worst Space Debris Events of All Time]

But unlike terrestrial artifacts, orbiting objects are barely visible to us and are not designed to interact with human bodies (with a few notable exceptions, such as the International Space Station)..

"They may represent the beginnings of a technological trajectory that will transform how human cultures relate to time and space," Gorman said.

Representatives of Homo sapiens

In a session at the SAA conference, Peter Capelotti of Penn State University reviewed dead or soon-to-be dead interplanetary spacecraft.

Capelotti noted that space probes navigating the boundaries between our solar system and interstellar space seem to represent "whole new categories of archaeological methodology ... if we are to consider the possibilities of heritage, preservation and, eventually, fieldwork."

For example, NASA's far-flung Pioneer 10, Pioneer 11, Voyager 1, Voyager 2 and New Horizons probes will "eventually enter interstellar space and become the archaeological representatives of Homo sapiens to the rest of the galaxy," Capelotti said.

Once a spacecraft no longer responds to signals from Earth, it ceases to be used for the original mission for which it was designed, and becomes instead a discarded, and hence, archaeological, object, Capelotti said.

Leonard David has been reporting on the space industry for more than five decades. He is former director of research for the National Commission on Space and is co-author of Buzz Aldrin?s new book ?Mission to Mars ? My Vision for Space Exploration? out in May from National Geographic.?Follow us?@Spacedotcom,?Facebook?or?Google+. Originally published on?SPACE.com.

Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/space-archaeologists-call-preserving-off-earth-artifacts-161737198.html

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Wednesday, April 24, 2013

Scientists map all possible drug-like chemical compounds

Tuesday, April 23, 2013

Drug developers may have a new tool to search for more effective medications and new materials.

It's a computer algorithm that can model and catalogue the entire set of lightweight, carbon-containing molecules that chemists could feasibly create in a lab.

The small-molecule universe has more than 10^60 (that's 1 with 60 zeroes after it) chemical structures. Duke chemist David Beratan said that many of the world's problems have molecular solutions in this chemical space, whether it's a cure for disease or a new material to capture sunlight.

But, he said, "The small-molecule universe is astronomical in size. When we search it for new molecular solutions, we are lost. We don't know which way to look."

To give synthetic chemists better directions in their molecular search, Beratan and his colleagues -- Duke chemist Weitao Yang, postdoctoral associates Aaron Virshup and Julia Contreras-Garcia, and University of Pittsburgh chemist Peter Wipf -- designed a new computer algorithm to map the small-molecule universe.

The map, developed with a National Institutes of Health P50 Center grant, tells scientists where the unexplored regions of the chemical space are and how to build structures to get there. A paper describing the algorithm and map appeared online in April in the Journal of the American Chemical Society.

The map helps chemists because they do not yet have the tools, time or money to synthesize all 10^60 compounds in the small-molecule universe. Synthetic chemists can only make a few hundred or a few thousand molecules at a time, so they have to carefully choose which compounds to build, Beratan said.

The scientists already have a digital library describing about a billion molecules found in the small-molecule universe, and they have synthesized about 100 million compounds over the course of human history, Beratan said. But these molecules are similar in structure and come from the same regions of the small-molecule universe.

It's the unexplored regions that could hold molecular solutions to some of the world's most vexing challenges, Beratan said.

To add diversity and explore new regions to the chemical space, Aaron Virshup developed a computer algorithm that built a virtual library of 9 million molecules with compounds representing every region of the small-molecule universe.

"The idea was to start with a simple molecule and make random changes, so you add a carbon, change a double bond to a single bond, add a nitrogen. By doing that over and over again, you can get to any molecule you can think of," Virshup said.

He programed the new algorithm to make small, random chemical changes to the structure of benzene and then to catalogue the new molecules it created based on where they fit into the map of the small-molecule universe. The challenge, Virshup said, came in identifying which new chemical compounds chemists could actually create in a lab.

Virshup sent his early drafts of the algorithm's newly constructed molecules to synthetic chemists who scribbled on them in red ink to show whether they were synthetically unstable or unrealistic. He then turned the criticisms into rules the algorithm had to follow so it would not make those types of compounds again.

"The rules kept us from getting lost in the chemical space," he said.

After ten iterations, the algorithm finally produced 9 million synthesizable molecules representing every region of the small-molecule universe, and it produced a map showing the regions of the chemical space where scientists have not yet synthesized any compounds.

"With the map, we can tell chemists, if you can synthesize a new molecule in this region of space, you have made a new type of compound," Virshup said. "It's an intellectual property issue. If you're in the blank spaces on our small molecule map, you're guaranteed to make something that isn't patented yet," he said.

The team has made the source code for the algorithm available online. The researchers said they hope scientists will use it to immediately start mining the unexplored regions of the small molecule universe for new chemical compounds.

###

Duke University: http://www.duke.edu

Thanks to Duke University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 62 time(s).

Source: http://www.labspaces.net/127863/Scientists_map_all_possible_drug_like_chemical_compounds

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Amgen 1Q profit rises 21 percent on drug sales

(AP) ? Biotech giant Amgen Inc. says its first-quarter profit rose 21 percent on higher sales of drugs to treat arthritis and osteoporosis.

The company on Tuesday reported net income of $1.43 billion, or $1.88 per share, from $1.18 billion, or $1.48 per share, in the prior-year period. Adjusted earnings were $1.96 per share.

Revenue rose 5 percent, to $4.24 billion.

Analysts polled by FactSet expect earnings per share of $1.84 on sales of $4.37 billion.

Sales of the Thousand Oaks, Calif., company's biotech drugs were driven by growth of Enbrel for psoriasis and rheumatoid arthritis and Prolia for osteoporosis.

Sales of anemia drugs Aranesp and Epogen continued their long slide due to limits on dosing and reimbursement because of safety concerns.

Shares are off 4.7 percent to $107.42 in after-hours trading.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-23-Earns-Amgen/id-6e8ada0d5bfa4412b040cc5e296d617e

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Will.i.am Admits "Let's Go" Beat Stolen From Arty & Mat Zo!

Source: http://www.thehollywoodgossip.com/2013/04/william-lets-go-beat-actually-stolen-from-arty-and-mat-zo/

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'Vanilla Ice Goes Amish' to debut on DIY this year

NEW YORK (AP) ? The DIY television network is proving a comfortable home for rappers turned renovators.

"Vanilla Ice Goes Amish" will debut on the network this year. Network executive Burton Jablin says the former rap star will live with an Amish community in Ohio to learn how they do construction. Vanilla Ice already has a renovation series on the network that will return for its fourth season this fall.

Reverend Run of Run DMC will have a series next year starring with his wife and three children as they renovate their home.

Keeping with the music theme, DIY will also feature Daryl Hall next year as he renovates a farmhouse in Connecticut.

Source: http://news.yahoo.com/vanilla-ice-goes-amish-debut-diy-183523526.html

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More rain expected for already swollen Midwest rivers

CLARKSVILLE, Mo. (AP) ? Communities along the Mississippi River and other Midwestern waterways are vigilantly eyeing ? and in some cases hastily fortifying ? makeshift levees to hold back floodwaters that meteorologists say could worsen or be prolonged by looming storms.

An inch of rain was expected to fall from Oklahoma to Michigan through Tuesday, a new drenching that led the National Weather Service to heighten the forecast crest of some stretches of rivers while blunting the progress of other waterways' slow retreat.

Mark Fuchs, a National Weather Service hydrologist, said the latest dousing could be especially troubling for communities along the Illinois River, which he said is headed for record crests.

"Along the Illinois, any increase is going to be cause for alarm, adding to their uncertainty and, in some cases, misery," he said late Monday afternoon.

Last week's downpours brought on sudden flooding throughout the Midwest, and high water is blamed for at least three deaths. Authorities in LaSalle, Ill., spent Monday searching for a woman whose van was spotted days earlier near a bridge, and a 12-year-old boy was in critical condition after being pulled from a river near Leadwood, Mo., about 65 miles south of St. Louis.

The additional rain isn't welcome news in Clarksville, Mo., about 70 miles north of St. Louis.

Days after bused-in prison inmates worked shoulder to shoulder with the National Guard and local volunteers to build a makeshift floodwall of sand and gravel, the barrier showed signs of strain Monday. Crews scrambled to patch trouble spots and build a second sandbag wall to catch any water weaseling through.

In Grafton, Ill., some 40 miles northeast of St. Louis, Mayor Tom Thompson said small community was holding its own against the Mississippi that by early Monday afternoon was 10 feet above flood stage. Waters lapped against some downtown buildings, forcing shops such as Hawg Pit BBQ to clear out and detours to be put up around town ? one key intersection was under 8 inches of water.

"If it gets another foot (higher), it's going to become another issue," Thompson said. Many businesses "are kinda watching and holding their breath. ... Some things are going to really be close to the wire."

Elsewhere, smaller rivers caused big problems. In Grand Rapids, Mich., the Grand River hit a record 21.85 feet, driving hundreds of people from their homes and flooding parts of downtown.

Spots south of St. Louis aren't expected to crest until late this week, and significant flooding is possible in places like Ste. Genevieve, Mo., Cape Girardeau, Mo., and Cairo, Ill. Further downriver, flood warnings have been issued for Kentucky and Tennessee.

___

Salter reported from St. Louis.

Source: http://news.yahoo.com/more-rain-expected-already-swollen-rivers-070400840.html

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